為促進(jìn)骨科學(xué)術(shù)交流和技術(shù)創(chuàng)新，汕頭大學(xué)醫(yī)學(xué)院第一附屬醫(yī)院中德骨科交流中心于2024年11月29日邀請(qǐng)柏林夏洛特大學(xué)綜合醫(yī)院Julius Wolff研究所創(chuàng)始主任、哈佛大學(xué)Wyss生物啟發(fā)工程研究所國(guó)際學(xué)者Georg Duda教授進(jìn)行主題演講（線上），汕頭大學(xué)醫(yī)學(xué)院附屬第一醫(yī)院骨科胡軍教授致辭并主持會(huì)議。Duda教授以“影響骨愈合的生物和物理因素”為題，深入探討骨再生治療的難點(diǎn)與新進(jìn)展。其領(lǐng)導(dǎo)的團(tuán)隊(duì)聚焦骨愈合早期階段，發(fā)現(xiàn)骨折斷面形成血腫后會(huì)出現(xiàn)系列炎性反應(yīng)，若炎性無(wú)法正常消退，會(huì)阻礙骨再生。通過(guò)對(duì)大數(shù)據(jù)的研究，他們發(fā)現(xiàn)CD8+TEMRA細(xì)胞是關(guān)鍵干擾因子，并嘗試使用藥物減少其影響，顯著改善骨愈合效果。此外，團(tuán)隊(duì)研究揭示了血管生成缺陷也是骨愈合失敗的重要原因，發(fā)現(xiàn)固定方式對(duì)血管生成有重要影響。此外，Duda教授還分享了3D生物打印技術(shù)的進(jìn)展，利用HUVEC和hMSC細(xì)胞優(yōu)化了微血管網(wǎng)絡(luò)打印材料，并介紹了新型粘彈性骨替代支架。這種載體具有優(yōu)異的應(yīng)力松弛性能，能夠顯著提升骨再生效率，目前正進(jìn)行臨床試驗(yàn)。此外，本次會(huì)議還邀請(qǐng)了許建坤教授進(jìn)行題為“骨科中以鎂元素植入物在臨床使用的科研基礎(chǔ)”的演講。許建坤教授介紹道，鎂基可降解金屬在骨科中的應(yīng)用因其生物相容性和成骨活性日漸受到關(guān)注。其團(tuán)隊(duì)長(zhǎng)期研究表明，鎂在降解過(guò)程中釋放鎂離子和氫氣，能調(diào)節(jié)骨組織細(xì)胞、感知神經(jīng)和骨膜干細(xì)胞的功能。鎂離子通過(guò)刺激感覺(jué)神經(jīng)釋放降鈣素基因相關(guān)肽（CGRP），促進(jìn)成骨細(xì)胞分化，加速骨折愈合，并顯著減少骨纖維化，此外，鎂的局部釋放和免疫調(diào)節(jié)機(jī)制同樣對(duì)骨愈合過(guò)程發(fā)揮重要作用。該研究能夠?yàn)楣琴|(zhì)疏松性骨折等復(fù)雜骨病治療提供新策略，并推動(dòng)了鎂材料的臨床轉(zhuǎn)化。會(huì)議期間，在場(chǎng)的年輕醫(yī)生及研究生積極發(fā)問(wèn)，與兩位講者進(jìn)行深入的探討，獲取了寶貴的建議。視頻會(huì)議結(jié)束之際，胡軍教授致謝Duda教授及許建坤教授的精彩學(xué)術(shù)分享，并表示期待未來(lái)雙方能開(kāi)展更加深入的學(xué)術(shù)交流與合作。本次學(xué)術(shù)會(huì)議開(kāi)闊國(guó)際視野，為骨科學(xué)科建設(shè)注入了新思路、新動(dòng)力。汕頭大學(xué)醫(yī)學(xué)院第一附屬醫(yī)院骨科將繼續(xù)推動(dòng)學(xué)術(shù)國(guó)際化發(fā)展，促進(jìn)骨科創(chuàng)新研究及生物材料轉(zhuǎn)化應(yīng)用。

To promote academic exchanges and technical innovation of orthopedics, the Sino-German Communication Center for Orthopedics of the First Affiliated Hospital of Shantou University Medical College invited Prof. Georg Duda, Director of Julius Wolff Institute of Charité–University Medicine Berlin and International Faculty Member of the Wyss Institute for Biologically Inspired Engineering of Harvard University, to give a special lecture online on November 29th, 2024.Prof. HU Jun from the Department of Orthopedics of the First Affiliated Hospital of Shantou University Medical College addressed a welcome speech and moderated the webinar. Prof. Duda gave an in-depth talk entitled "How Biological and Physical Factors Affect Bone Healing" on the difficulties and new improvement of bone regeneration therapy. His team focused on the first two stages of bone healing process, and found that if disorders in the downregulation of inflammation happen after hematoma forms at the surface of fracture, there will be problems in bone healing. With the study on big data, the team proved that CD8+TEMRA cell is a key factor to interfere bone healing. So they did drug trials to reduce these cells so as to improve bone healing. Meanwhile, Prof. Duda's team also discovered from research that the impairment in angiogenesis is also a key reason for bone healing failure, and that rigid and semi-rigid fixation lead to different result of angiogenesis. Moreover, Prof. Duda shared the progress of 3D bio-printing technology of printing vessels with HUVECs and hMSCs to form highly-organized microvascular structures. And he also introduced a new viscoelastic bone fracture scaffold. This kind of scaffold with lower stiffness can efficiently improve bone formation in the scaffold and is now under clinical trials. Following that, this webinar also invited Prof. XU Jiankun to give a lecture on "Scientific Foundation for the Application of Magnesium-based Devices in Orthopedics". According to Prof. XU Jiankun, the application of magnesium-based biodegradable metal in orthopedics is attracting more and more attention due to its properties. According to long-term research, magnesium releases magnesium ions and hydrogen and can regulate the function of cells in the bone, sensory neurons and periosteum-derived stem cells (PDSCs).Magnesium ions can stimulate sensory neurons to release CGRP which has influence on differentiation of PDSCs and accelerates bone healing. And magnesium-based biodegradable metals can also reduce fibrosis significantly. In addition, magnesium's local release and immunomodulatory effects also play key roles in bone healing process. This research will provide novel strategies for treating complex bone diseases, such as osteoporotic fractures, and promote the clinical application of magnesium-based materials. During the webinar, the young surgeons and postgraduates onsite were active in raising questions and having in-depth discussions with the two professors, obtaining valuable advice. At the end of the webinar, Prof. HU Jun thanked Prof. Duda and Prof. XU Jiankun for their wonderful academic sharing and looked forward to deeper academic exchanges and cooperation between both sides. This academic conference broadened the international vision and injected new ideas and new inspirations for the construction of orthopedic specialty. The Department of Orthopedics of the First Affiliated Hospital of Shantou University Medical College will continuously promote its academic development at an international stage, innovative research in orthopaedics and translational application of biomaterials.